Prednisolone is a synthetic analogue of the hormones cortisone and hydrocortisone. It has anti-inflammatory, antiallergic, antiexudative, antishock, anti-toxic effects.

Common use

Prednisolone is a synthetic analogue of the hormones cortisone and hydrocortisone. The drug causes significant anti-inflammatory, antiallergic, antiexudative, antishock, anti-toxic effects. Anti-inflammatory effect of prednisolone is achieved mainly associated with cytosolic glucocorticosteroid receptors. The complex between the hormone and the receptor penetrates into the nucleus of the target skin cell enhances expression of the genes that code synthesis of lipokortins, the substances which inhibits phospholipase A2 and reduce the synthesis of metabolic products of arachidonic acid cyclic known to participate in inflammatory reaction. Antiallergic effect of the drug is explained by its ability to decrease number of basophils and inhibit synthesis and secretion of biologically active substances. Prednisolone is used to treat many different conditions such as allergic disorders, collagenosis (skin conditions), infectious nonspecific polyarthritis, psoriasis, lupus, ulcerative colitis, bronchial asthma, acute lymphoblastic and myeloid leukemia, neurodermatitis, eczema, Addison disease (decreased adrenal function), and many others.



Dosage and direction

Individual dosing is necessary for each condition. Acute conditions and initial dose are usually 5-60 mg a day. Maintenance dose is usually 5-10 mg a day. Do not take more of Prednisolone than it was prescribed to you. Follow all recommendations of your doctor.



Precautions

Inform your doctor about all diseases you have and especially about liver or kidney disease, a thyroid disorder, diabetes, tuberculosis, malaria, myasthenia gravis, stomach ulcerations, glaucoma, mental illness as use of the steroid may influence these conditions. Steroid medications are known to weaken immune system, so it may become easier for you to be infected anew or your existing infection may worsen. Inform your doctor if you have been sick recently with infection. Avoid sick people. Inform your doctor if you contact with people with chicken pox or measles, because these diseases maybe fatally dangerous to people treated by steroids. You should not be vaccinated by ?live? vaccines during treatment with Prednisolone. Do not interrupt treatment with Prednisolone suddenly to avoid unpleasant withdrawal symptoms. Inform your doctor about your pregnancy.



Contraindications

This medication cannot be used in the patients with severe hypertension, diabetes and Itsenko-Cushing syndrome, in pregnant women, severe circulatory failure, acute endocarditis (inflammation of the inner cavities of the heart), psychosis, nephritis, osteoporosis, stomach and duodenal ulcers, recently surgery, syphilis, active form of tuberculosis, in elderly patients.



Side effects

This medication may be a reason of obesity, hirsutism (excess body hair growth in women), acne, menstrual disorders, osteoporosis, Itsenko-Cushing syndrome (obesity, decreased sexual function, bone fragility), gastrointestinal ulcerations, ulcer perforation, hemorrhagic pancreatitis, hyperglycemia (high blood sugar), increase in blood clotting, mental disorders. Withdrawal symptoms are possible especially after long treatment. Other side effects which should be informed about to your doctor if they worsen are changes in vision, depression, seizures, bloody or tarry stools, low potassium (increased urination, extreme thirst, uneven heart rate), hypertension.



Drug interaction

Concomitant use of Prednisolone and anti-diabetic and and anticoagulant drugs requires correction of the doses. In the patients with Addison disease concomitant use of Prednisolone and barbiturates should be exercised with cautiousness.



Missed dose

If you forgot to take your dose in time, contact your doctor or health care advisor.



Overdose

This medication is not likely to cause life-threating symptoms. Dangerous conditions may be caused by prolonged use of the medication: easy bruising, thinning skin, body fat located in the back, face, neck, and waist,acne or facial hair growth, impotence, menstrual problems.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.